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The sudden drop in signals at the moment of sensory detection or food cognition may reflect the abrupt recognition of an anticipated resolution of energy deficit, rather than being driven by ingestive or hormonal signals which typically act over minutes to hours [50]

For instance, quantitative flux analysis of NADPH, which employs tracking of deuterium incorporation into NADPH, has revealed that folate-dependent methylenetetrahydrofolate dehydrogenase (MTHFD)-mediated NADPH production provides anti-oxidant activity to cells and enables resistance to oxidative stress (68)

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10.1189/jlb.0609406 J Leukoc Biol

Experimental Design and Methodology The study used both male and female 5xFAD transgenic mice, aged four months at the onset of testing